Senior Deborah Abeles belted a homerun to add to her Harvard career record, and fellow senior Ghia Godfree doubled in the other Crimson run.
Abeles set a Harvard record with 17 career homeruns last year while leading the Ivy League with a .411 batting average and earning First Team All-Ivy honors.
Sophomore star Sarah Koppel, a First Team All-Ivy selection her rookie year, continued to impress, going 2-for-2 with a double and a single.
Fellow sophomore Cherry Fu added a single and a pair of runs to round out the scoring in the Crimson's six-hit rout.
In the early game, dominant pitching was again the story as Harvard junior Chelsea Thoke and St. John's Gina Calabrese combined for 24 strikeouts in a classic softball duel from the mound.
A pair of early runs by the Red Storm, however, would come back to haunt Harvard as St. John's picked up a nail-biting 2-1 victory.
Down 2-0 in the seventh and final inning, the Crimson mounted a late comeback as junior Mairead McKendry drilled a solo homer to pull Harvard to within one.
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